Trials / Completed
CompletedNCT00978653
The Effect of Uric Acid Decrement on Endothelial Function in Patients With Chronic Renal Failure
Prospective Study of Allopurinol Treatment That Improves Endothelial Function by Decreasing Uric Acid Levels of Patients With Chronic Kidney Disease
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 20 (actual)
- Sponsor
- Istanbul University · Academic / Other
- Sex
- All
- Age
- 18 Years – 60 Years
- Healthy volunteers
- Not accepted
Summary
In this prospective study, the investigators aimed to evaluate the effects of improved hyperuricemia, a minor cardiovascular risk factor, on endothelial dysfunction in patients with chronic kidney disease.
Detailed description
Endothelial dysfunction (ED) is a key event in the development of atherosclerotic cardiovascular disease observed in patients with chronic kidney disease (CKD). Experimental models have shown that hyperuricemia causes hypertension and renin angiotensin system activation. In this prospective study, the investigators aimed to evaluate the effects of improved hyperuricemia, a minor cardiovascular risk factor, on ED in patients with CKD.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | allopurinol | 150 mg once a day |
Timeline
- Start date
- 2008-04-01
- Primary completion
- 2009-03-01
- Completion
- 2009-05-01
- First posted
- 2009-09-17
- Last updated
- 2009-09-22
Locations
1 site across 1 country: Turkey (Türkiye)
Source: ClinicalTrials.gov record NCT00978653. Inclusion in this directory is not an endorsement.