NCT00954109

Acute Cardiovascular and Metabolic Effects of Exercise Training in Individuals With Insulin Resistance

Physical Inactivity and Insulin Resistance in Skeletal Muscle

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 11 (actual)
• Sponsor: US Department of Veterans Affairs · Federal
• Sex: All
• Age: 30 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The overall aim of the project is to determine whether or not exercise influences cardiovascular or nervous responses to meal ingestion in individuals with insulin resistance or type 2 diabetes.

Detailed description

Participants will undergo a screening procedure, including telephone screening and physical examination, as well as determination of body composition and fitness. Participants will be asked to complete 5-10 days of supervised exercise training and will undergo testing to assess cardiovascular and metabolic responses to an oral glucose tolerance test, including muscle sympathetic nerve activity, blood flow, and circulating glucose and insulin concentrations at baseline and following training. In addition, day-to-day variations in blood glucose will also be monitored. The overall aim of the project is to determine whether or not acute exercise training influences postprandial metabolic, vascular or autonomic nervous system responses in individuals with insulin resistance or T2D.

Conditions

• Insulin Resistance

Interventions

Type	Name	Description
BEHAVIORAL	Exercise	daily exercise: supervised treadmill walking or cycle ergometry use

Timeline

• Start date: 2009-08-01
• Primary completion: 2010-12-01
• Completion: 2010-12-01
• First posted: 2009-08-07
• Last updated: 2015-04-06
• Results posted: 2015-04-06

Locations

1 site across 1 country: United States