Trials / Terminated
TerminatedNCT00952185
Influenza Vaccine in Preventing Flu in Patients Who Have Undergone Stem Cell Transplant and in Healthy Volunteers
Clinical Correlates of Immunologic Responses to the Flu Vaccine
- Status
- Terminated
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 9 (actual)
- Sponsor
- City of Hope Medical Center · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
RATIONALE: The influenza vaccine may help prevent flu in patients who have undergone stem cell transplant. PURPOSE: This clinical trial is studying how well the influenza vaccine works in preventing flu in patients who have undergone stem cell transplant and in healthy volunteers.
Detailed description
OBJECTIVES: * To examine the incidence rate of influenza infection over two flu seasons in patients who have undergone hematopoietic stem cell transplantation at the City of Hope National Medical Center. * To correlate influenza infection with graft-vs-host disease, age, and transplant type in these patients. * To examine and compare the incidence rate of influenza in healthy volunteers to the incidence rate in these patients. OUTLINE: Beginning approximately 2 weeks after vaccination or the onset of flu season, patients and healthy participants undergo nasopharyngeal washes every 14-17 days (2-10 washes) during the months of November-March of the 2008-2009 and 2009-2010 flu seasons. Samples are analyzed by direct fluorescent antibodies. Patients and participants complete case report forms detailing flu-like symptoms experienced in the 2 weeks before sample collection. PROJECTED ACCRUAL: A total of 150 patients and 75 healthy volunteers will be accrued for this study.
Conditions
- Brain and Central Nervous System Tumors
- Chronic Myeloproliferative Disorders
- Leukemia
- Lymphoma
- Lymphoproliferative Disorder
- Multiple Myeloma and Plasma Cell Neoplasm
- Myelodysplastic Syndromes
- Myelodysplastic/Myeloproliferative Neoplasms
- Nonmalignant Neoplasm
- Viral Infection
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | cytology specimen collection procedure | |
| OTHER | fluorescent antibody technique | |
| PROCEDURE | assessment of therapy complications |
Timeline
- Start date
- 2008-11-01
- Primary completion
- 2010-06-01
- Completion
- 2010-06-01
- First posted
- 2009-08-06
- Last updated
- 2015-06-08
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT00952185. Inclusion in this directory is not an endorsement.