NCT00948558

Citrate Pharmacokinetics and Regional Citrate Anticoagulation in CRRT

Citrate Pharmacokinetics in Healthy Individuals and Critically Ill Patients and the Application of Regional Citrate Anticoagulation in Continuous Renal Replacement Therapy(RCA-CRRT).

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 40 (estimated)
• Sponsor: Huashan Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

1. To compare the differences of citrate pharmacokinetics in healthy individuals and critically ill patients as well as the influential factors. 2. To validate a pharmacokinetic model which has been established in a formal paper. 3. To create a safe and effective RCA-CRRT protocol.

Conditions

• Acute Kidney Failure With or Without:
• MODS
• Sepsis
• Hepatic Insufficiency

Timeline

• Start date: 2009-03-01
• Primary completion: 2010-12-01
• Completion: 2011-09-01
• First posted: 2009-07-29
• Last updated: 2009-08-06

Locations

1 site across 1 country: China