NCT00942110

Alterations in Postprandial Glucose and Lipid Metabolism in Patients With Obstructive Sleep Apnea

Examination of Association Between Glucose, Lipid Metabolism and Obstructive Sleep Apnea

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 58 (actual)
• Sponsor: Kyoto University, Graduate School of Medicine · Academic / Other
• Sex: All
• Age: 20 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to examine postprandial glucose and lipid metabolism in patients with obstructive sleep apnea.

Detailed description

Obstructive sleep apnea (OSA) is an increasingly prevalent condition that is characterized by repetitive upper airway obstructions. OSA has been independently associated with insulin resistance, suggesting that OSA may contribute to the development of type 2 diabetes and the metabolic syndrome. Recently, postprandial glucose and lipid have been reported as excellent predictors for mortality and cardiovascular risk. However, the association between postprandial glucose, lipid metabolism and OSA are not clear. In addition, humoral factors such as ghrelin and leptin are associated with obesity and OSA, but postprandial changes of which in patients with OSA are not well known. The aim of present study is to examine postprandial glucose and lipid metabolism, humoral factors in OSA before and after 3 months of continuous positive airway pressure (CPAP) treatment.

Conditions

• Obstructive Sleep Apnea

Interventions

Type	Name	Description
DEVICE	CPAP treatment	maintains upper airway patency and minimizes the obstructive events

Timeline

• Start date: 2009-09-01
• Primary completion: 2011-12-01
• Completion: 2012-03-01
• First posted: 2009-07-20
• Last updated: 2012-03-06

Locations

1 site across 1 country: Japan