NCT00931775

Citalopram Versus Citalopram Plus Pindolol in Major Depressive Disorder

Citalopram Versus Citalopram Plus Pindolol in Latency of Antidepressant Response Shortening in Major Depressive Disorder

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to examine whether the speed of the clinical antidepressant action of citalopram can be accelerated by administering double doses of pindolol (15 mg/day, tid) which presumably should lead to increased 5-HT1A autoreceptor occupancy.

Detailed description

Design, Settings, and Participants. A randomised, double-blind, placebo-controlled trial with MDD patients allocated to two treatment arms: citalopram + pindolol versus citalopram + placebo. Participants: outpatients with a depressive episode (DSM-IV criteria) were selected from a general hospital.

Conditions

• Major Depressive Disorder
• Antidepressant Treatment Response

Interventions

Type	Name	Description
DRUG	Pindolol	Pill orally administered. 15 mg/day t.i.d.

Timeline

• Start date: 2002-12-01
• Primary completion: 2005-03-01
• Completion: 2005-11-01
• First posted: 2009-07-02
• Last updated: 2009-07-02

Locations

1 site across 1 country: Spain