NCT00928954

Cross-over Comparison of Gabapentin and Memantine as Treatment for Acquired Nystagmus

Investigation and Treatment of Ocular Motor Disorders: Cross-over Comparison of Gabapentin and Memantine as Treatment for Nystagmus

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: Case Western Reserve University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Involuntary oscillations of the eyes (nystagmus) impairs vision so that affected patients, who have neurological disorders such as Multiple Sclerosis (MS) , cannot read or watch TV. Two medicines have been reported to suppress nystagmus and improve vision in such patients: gabapentin and memantine. The investigators set out to test which of these two drug was more effective by carrying out a double-blind cross-over study. In this way, we could determine which drug worked best in each patient.

Detailed description

The study entails careful measurements of visual acuity and precise measurements of eye movements, using a contact lens device (magnetic search coil method). In this way, it is possible to make objective and reliable measurements of the effect of each drug, which are unbiased by the investigator or the patient.

Conditions

• Nystagmus

Interventions

Type	Name	Description
DRUG	gabapentin	increasing to 1200 mg/day
DRUG	memantine	increasing to 40 mg/day

Timeline

• Start date: 2005-02-01
• Primary completion: 2009-05-01
• Completion: 2009-05-01
• First posted: 2009-06-26
• Last updated: 2016-07-29
• Results posted: 2016-07-29

Locations

1 site across 1 country: United States