NCT00927004

Efficacy of Etoricoxib 60 mg in Modifying Pain Hypersensitivity in People With Knee Osteoarthritis

A Randomised Placebo-controlled Trail of Mechanical and Cold Hyperalgesia in Subjects With Painful Knee Osteoarthritis, Compared With Matched Controls, & Whether This Hyperalgesia Can be Modified by a 2-week Course of Etoricoxib 60mg.

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: Curtin University · Academic / Other
• Sex: All
• Age: 50 Years
• Healthy volunteers: Accepted

Summary

This study aims to better understand the way in which painful osteoarthritis affects different people and whether an anti-inflammatory medication such as Arcoxia (etoricoxib) can help to modify this pain. The study will use questionnaires and tests of pain sensitivity to identify arthritis sufferers with more widespread, nerve-type pain and then to investigate whether a daily dose of Arcoxia is more effective than a placebo pill in reducing these symptoms and improving functional movements. The study will also be comparing the same test results of a small group of subjects without knee pain.

Conditions

• Osteoarthritis
• Pain

Interventions

Type	Name	Description
DRUG	Etoricoxib (Arcoxia)	60 mg, daily dose, oral delivery, 14 days duration
DRUG	Sugar pill	Daily dose (1 pill), oral delivery, 14 days

Timeline

• Start date: 2010-08-01
• Primary completion: 2011-11-01
• Completion: 2011-12-01
• First posted: 2009-06-24
• Last updated: 2012-05-03

Locations

1 site across 1 country: Australia