NCT00924677

The Effect of Therapeutic Methods for Chronic Knee Osteoarthritis Pain

Phase 1 Study of Therapeutic Methods for Chronic Knee Osteoarthritis Pain

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 38 (actual)
• Sponsor: Asan Medical Center · Academic / Other
• Sex: All
• Age: 50 Years – 80 Years
• Healthy volunteers: Accepted

Summary

Chronic osteoarthritis (OA) pain of the knee is not effectively abrogated by the available non-pharmacologic or pharmacologic treatments. Radiofrequency (RF) neurotomy is a therapeutic alternative for chronic pain. Here, the researchers investigate the efficacy of RF neurotomy applied to articular branches (genicular nerves) in treating knee joint pain.

Detailed description

The knee joint is innervated by articular branches of various nerves (femoral, common peroneal, saphenous, tibial and obturator) (Kennedy et al. 1982; Hirasawa et al. 2000). These articular branches around the knee joint are known as genicular nerves. Several genicular nerves can be easily approached percutaneously under fluoroscopic guidance. In our study, genicular nerves were effectively blocked with local anesthetics under fluoroscopic guidance, leading to a significant reduction in knee pain. Rf neurotomy is based on the theory that cutting the nerve supply to a painful structure may alleviate pain and restore function. we evaluate the efficacy of RF neurotomy in reducing pain and improving function in the elderly with chronic knee OA.

Conditions

• Osteoarthritis, Knee

Interventions

Type	Name	Description
PROCEDURE	radiofrequency neurotomy for genicular nerve	RF cannula was advanced percutaneously towards areas connecting the shaft to epicondyle of femur or tibia. Lidocaine (1 mL of 2%) was injected before activation of the RF generator (NeuroThermTM, Morgan automation LTD, Liss, UK). RF electrode was inserted through RF cannula. The temperature of the electrode tip was raised to 70℃ for 90 seconds by radiofrequency generator.
PROCEDURE	radiofrequency neurotomy sham therapy	The placebo (sham) group received the same procedure without activation of the RF generator.

Timeline

• Start date: 2009-01-01
• Primary completion: 2009-04-01
• Completion: 2009-06-01
• First posted: 2009-06-19
• Last updated: 2009-06-19

Locations

1 site across 1 country: South Korea