NCT00919243

Prednisone for Heart Failure Patients With Hyperuricemia

Prednisone Versus Allopurinol for Symptomatic Heart Failure Patients With Hyperuricemia

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Hebei Medical University · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Hyperuricemia is a very common finding in patients with heart failure. It is usually related to diuretic use and deteriorated renal function. The recently evidence showed that uric acid (UA) lowering therapy may improve clinical status in symptomatic heart failure patients with hyperuricemia. In their clinical practice, the investigators found that glucocorticoids could dramatically lower UA while improving renal function. Thus the investigators design this randomized head to head study to test our hypothesis that prednisone have the same efficacy to allopurinol on lowering UA and could improve renal function at the same time.

Conditions

• Heart Failure
• Hyperuricemia

Interventions

Type	Name	Description
DRUG	prednisone	1 mg/kg/day with a maximum dose of 60 mg/day given orally
DRUG	allopurinol	allopurinol, the dose of allopurinol is adjusted by patients' renal function, and with a maximum dose of 300mg/day.

Timeline

• Start date: 2009-02-01
• Primary completion: 2010-07-01
• Completion: 2010-08-01
• First posted: 2009-06-12
• Last updated: 2010-09-01

Locations

1 site across 1 country: China