Trials / Completed

CompletedNCT00915798

Association Between Smoking, Brain Activity, Genes, and ADHD

Smoking, Neurocircuitry and Genes in Adult ADHD

Status: Completed
Phase: —
Study type: Observational
Enrollment: 89 (actual)

Sponsor: University of California, Irvine · Academic / Other
Sex: All
Age: 18 Years – 45 Years
Healthy volunteers: Accepted

Summary

Detailed description

The study investigated the underlying mechanisms of smoking in young adults by examining the associations between smoking, brain activity, dopamine genes, and attention deficit hyperactivity disorder (ADHD). Four groups of young adults were recruited: (1) smokers with ADHD; (2) nonsmokers with ADHD; (3) normative control smokers; and (4) normative control nonsmokers. Smoking was assessed via questionnaires and salivary cotinine levels. Brain activity was examined via functional Magnetic Resonance Imaging (fMRI). Each nonsmoker underwent an fMRI scan during an experimental task consisting of mathematical problems. Smokers underwent two fMRI scans during similar experimental tasks under the following two conditions: (1) after smoking a cigarette and (2) after overnight abstinence. The association between the DRD4-7 repeat allele and smoking was explored.

Conditions

Interventions

Type	Name	Description
BEHAVIORAL	Cigarette smoking	Participants had an fMRI scan during an experimental task consisting of mathematical problems after smoking a cigarette.
BEHAVIORAL	Abstinence	Participants had an fMRI scan during an experimental task consisting of mathematical problems after smoking abstinence.

Timeline

Start date: 2009-07-01
Primary completion: 2016-01-01
Completion: 2016-06-01
First posted: 2009-06-08
Last updated: 2017-01-13
Results posted: 2017-01-13

Locations

1 site across 1 country: United States

Source: ClinicalTrials.gov record NCT00915798. Inclusion in this directory is not an endorsement.