NCT00914251

Vascular Effects of Hesperidin in Metabolic Syndrome

Positive Vascular Effect of Hesperidin in Subjects Affected by Metabolic Syndrome

• Status: Unknown
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: University of Rome Tor Vergata · Academic / Other
• Sex: All
• Age: 20 Years – 55 Years
• Healthy volunteers: Not accepted

Summary

It has been suggested that cardiovascular risk factors either independently or in cluster (metabolic syndrome) increase the risk of both type 2 diabetes (DM2) and cardiovascular diseases (CVD). Consumption of citrus fruits is linked to reduced cardiovascular morbidity and mortality. Hesperidin is a flavanone abundant in citrus fruit with putative vasodilator actions in vitro. While molecular mechanisms of vascular actions of hesperidin begin to be explored, no data on in vivo vascular effect of this flavanone has been ever acquired.

Conditions

• Endothelial Dysfunction
• Metabolic Syndrome

Interventions

Type	Name	Description
DRUG	Hesperidin	Administration of oral Hesperidin, 500 mg/daily
DRUG	Placebo	Administration of oral Placebo, 500 mg/daily

Timeline

• Start date: 2008-11-01
• Primary completion: 2009-03-01
• Completion: 2010-12-01
• First posted: 2009-06-04
• Last updated: 2009-06-17

Locations

1 site across 1 country: Italy