NCT00908999

Functional Magnetic Resonance Imaging (fMRI) of Anosognosia in Amnestic Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD)

FMRI of Anosognosia in Amnestic MCI and AD: Focus on Cortical Midline Structures

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 60 (estimated)
• Sponsor: University of Wisconsin, Madison · Academic / Other
• Sex: All
• Age: 60 Years – 90 Years
• Healthy volunteers: Accepted

Summary

This is a three year fMRI study conducted at the University of Wisconsin (UW) Hospital and the William. S. Middleton VA Hospital. This study is guided by the hypothesis that reduced fMRI activity and connectivity cortical midline structures (i.e., medial frontal and ventral posterior cingulate cortex) are physiologic abnormalities that relate strongly to the compromised insight into cognitive deficits, or anosognosia, shown by a subset of individuals with amnestic MCI (aMCI) and AD. Further, the investigators hypothesize that these regional changes in fMRI activity are predictive of faster progression from aMCI to AD.

Conditions

• Anosognosia
• Alzheimer's Disease
• Mild Cognitive Impairment

Timeline

• Start date: 2008-04-01
• Primary completion: 2011-09-01
• Completion: 2011-09-01
• First posted: 2009-05-27
• Last updated: 2011-09-29

Locations

1 site across 1 country: United States