NCT00899704

Biomarkers in Tissue Samples From Patients Who Have Undergone Neck Dissection for Oral Cancer

Molecular Mechanisms of OSCC Tumor Invasion

• Status: Withdrawn
• Phase: —
• Study type: Observational
• Enrollment: 0 (actual)
• Sponsor: Alliance for Clinical Trials in Oncology · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research study is looking at tissue samples in predicting oral cancer in patients who have undergone neck dissection for oral cancer.

Detailed description

OBJECTIVES: * To test preliminary data from node-positive oral squamous cell carcinoma (OSCC) signatures for their ability to predict lymph-positive primaries using a cohort of OSCC tumors. * To perform lymph node prediction using sentinel lymph node-biopsied primaries. * To validate the preliminary data node-positive OSCC signature and test its ability to predict nodal status. OUTLINE: Patient tissue samples are screened using polymerase chain reaction (PCR) for human papilloma virus-specific primers. Samples are analyzed to identify a nodal-metastasis signature for oral squamous cell carcinoma. Samples also undergo microarray analysis to quantify expression levels for targeted genes. Initial data analysis is performed using Affymetrix® Microarray Suite 5.0 to quantify expression levels for targeted genes.

Conditions

• Head and Neck Cancer

Interventions

Type	Name	Description
GENETIC	microarray analysis
GENETIC	allele-specific oligonucleotide real-time quantitative polymerase chain reaction
OTHER	diagnostic laboratory biomarker analysis

Timeline

• Start date: 2008-03-01
• Primary completion: 2008-03-01
• Completion: 2008-03-01
• First posted: 2009-05-12
• Last updated: 2019-01-30

Locations

1 site across 1 country: United States