NCT00899340

Protein Expression in Tumor Tissue Samples From Patients With Cancer of the Oropharynx

Protein Expression Profiles in Oropharyngeal Squamous Cell Carcinoma

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 54 (actual)
• Sponsor: Vanderbilt-Ingram Cancer Center · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

RATIONALE: Studying the proteins expressed in samples of tumor tissue from patients with cancer may help doctors identify and learn more about biomarkers related to cancer. It may also help doctors plan better treatment for patients with cancer of the oropharynx. PURPOSE: This laboratory study is looking at protein expression in tumor tissue samples from patients with cancer of the oropharynx.

Detailed description

OBJECTIVES: * To investigate if some of the differences in gene expression are also reflected at the protein level. * To determine whether differences in gene expression that are also reflected at the protein level can be used to develop markers for early detection and disease surveillance. * To identify targets for therapy. OUTLINE: Archived tumor tissue samples are analyzed for expression of standard immunohistological markers (e.g., p16, p53, and Ki-67) as well as expression of genes identified in a previous gene expression study. Protein expression data are tested for clinical and demographic correlates and compared with gene expression data.

Conditions

• Head and Neck Cancer

Interventions

Type	Name	Description
GENETIC	gene expression analysis	profiles of HPV(+) and (-) HNSCCs
GENETIC	microarray analysis	microarray analysis
GENETIC	protein expression analysis	protein expression analysis
OTHER	immunohistochemistry staining method	immunohistochemistry staining method
OTHER	laboratory biomarker analysis	laboratory biomarker analysis

Timeline

• Start date: 2006-05-01
• Primary completion: 2008-03-01
• Completion: 2008-03-01
• First posted: 2009-05-12
• Last updated: 2013-04-02