NCT00898794

Effect of Bevacizumab and VEGF on Platelet Clustering in Patients Who Are Receiving Bevacizumab for Cancer

Influence of Bevacizumab and VEGF on Platelet Aggregation

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 20 (estimated)
• Sponsor: Kantonsspital Graubuenden · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about the effect of bevacizumab and VEGF on platelet clustering. PURPOSE: This research study is looking at the effect of bevacizumab and VEGF on platelet clustering in patients with cancer who are receiving bevacizumab.

Detailed description

OBJECTIVES: * To determine the influence of bevacizumab on platelet aggregation in patients receiving bevacizumab for cancer. * To determine the influence of VEGF on platelet aggregation. * To determine the influence of VEGF or bevacizumab on cyclooxygenesis. * To determine if the sequence of medication plays a role in platelet aggregation. OUTLINE: Blood samples are collected before and after bevacizumab infusion. Samples are analyzed for measurements of platelet aggregation, coagulation parameters, and endothelial activation (e.g., fibrin fragment F1 and 2, thrombin and antithrombin complex, soluble P-selectin, Von Willebrand factor and factor VIII, tissue factor, and endothelin 1).

Conditions

• Unspecified Adult Solid Tumor, Protocol Specific
• Unspecified Childhood Solid Tumor, Protocol Specific

Interventions

Type	Name	Description
BIOLOGICAL	bevacizumab
OTHER	coagulation study
OTHER	laboratory biomarker analysis
OTHER	platelet aggregation test

Timeline

• Start date: 2007-10-01
• Primary completion: 2009-05-01
• First posted: 2009-05-12
• Last updated: 2013-08-07

Locations

1 site across 1 country: Switzerland