NCT00897052

Gene Expression Profiles in Predicting Survival of Patients With Head and Neck Cancer

Survival Prediction in HNSCC Based on Gene Expression Profiles From FFPE Tissues

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 29 (actual)
• Sponsor: Vanderbilt-Ingram Cancer Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict survival of patients with head and neck cancer. PURPOSE: This laboratory study is assessing gene expression profiles in predicting survival of patients with head and neck cancer.

Detailed description

OBJECTIVES: * Identify gene expression profiles associated with survival by DNA microarray assay analysis using RNA from formalin-fixed paraffin-embedded tissue samples from patients with squamous cell carcinoma of the head and neck treated on clinical trial RTOG-9501. OUTLINE: Formalin-fixed paraffin-embedded tissue samples are analyzed by DNA microarray analysis for gene expression profiling.

Conditions

• Head and Neck Cancer

Interventions

Type	Name	Description
GENETIC	microarray analysis	Assay RNA obtained from archived formalin fixed paraffin embedded tissue samples
OTHER	laboratory biomarker analysis	The gene expression data will be linked to the clinical information in order to generate profile of recurrence and survival as a biomarker.

Timeline

• Start date: 2005-02-01
• Primary completion: 2007-12-01
• Completion: 2007-12-01
• First posted: 2009-05-12
• Last updated: 2012-09-10