Trials / Completed
CompletedNCT00873496
Effects of Hydroxychloroquine on Oral Complaints of Sjögren Patients
Effects of Hydroxychloroquine on Oral Complaints of Sjögren Patients: a Prospective Sample Study.
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 30 (actual)
- Sponsor
- Ege University · Academic / Other
- Sex
- Female
- Age
- —
- Healthy volunteers
- Not accepted
Summary
Chronic inflammation that comprises the exocrine glands' function leads to xerophthalmia and xerostomia in Sjögren's syndrome. The oral consequences range widely and they are related to decreased salivary output. Hydroxychloroquine may inhibit cholinesterase activity in salivary glands via interference with antigen processing mechanism, and thus, the investigators' hypothesis was that salivary gland function may be improved if treated with hydroxychloroquine. The effects of hydroxychloroquine on the salivary flow rate, subjective and objective parameters of the patients were also assessed.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Hydroxychloroquine |
Timeline
- Start date
- 2005-01-01
- Primary completion
- 2008-10-01
- Completion
- 2009-01-01
- First posted
- 2009-04-01
- Last updated
- 2009-04-01
Locations
1 site across 1 country: Turkey (Türkiye)
Source: ClinicalTrials.gov record NCT00873496. Inclusion in this directory is not an endorsement.