NCT00853515

Goal-directed Fluid Resuscitation in Acute Pancreatitis

A Randomized-controlled Trial of a Targeted Approach to Fluid Resuscitation in Acute Pancreatitis

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Brigham and Women's Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Vigorous fluid resuscitation is currently believed to play a key role in reducing complications associated with acute pancreatitis. However, aggressive fluid replacement can be associated with complications such as pulmonary fluid sequestration. The purpose of this study is to evaluate alternative approaches to early fluid resuscitation for patients with acute pancreatitis.

Detailed description

Primary Aim: Evaluate the impact of a goal-directed fluid resuscitation protocol compared to standard fluid resuscitation on systemic inflammation in patients with acute pancreatitis. Secondary Aim: Evaluate the impact of resuscitation with Lactated Ringer's compared to normal saline on systemic inflammation in acute pancreatitis.

Conditions

• Acute Pancreatitis

Interventions

Type	Name	Description
OTHER	Goal-directed fluid resuscitation	Targeted, weight-based fluid resuscitation

Timeline

• Start date: 2009-03-01
• Primary completion: 2010-02-01
• Completion: 2010-06-01
• First posted: 2009-03-02
• Last updated: 2016-12-09

Locations

1 site across 1 country: United States