NCT00850629

Hormonal Regulation of Body Weight Maintenance

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 286 (actual)
• Sponsor: Charite University, Berlin, Germany · Academic / Other
• Sex: All
• Age: 10 Years – 90 Years
• Healthy volunteers: Accepted

Summary

The investigators here propose to perform a collaborative clinical research effort including a randomized controlled trial investigating the mechanisms of weight maintenance and their relation to a lifestyle intervention in children, adolescents and adults. The detailed investigation and analysis of the variability and dynamics of the endocrine circuits responding to a negative energy balance and weight loss will be accompanied and enhanced by specific clinical projects targeting peripheral and central-nervous aspects of hormonal counter-regulation after weight loss. Mechanisms of endocrine counter-regulation and potential therapeutic approaches will be studied.

Conditions

• Obesity
• Weight Loss
• Weight Gain
• Hormone Disturbance
• Adipose Tissue
• Insulin Resistance
• Skeletal Muscle

Interventions

Type	Name	Description
BEHAVIORAL	multimodal lifestyle intervention	After an initial weight loss, the weight regain will be measured during multimodal lifestyle intervention in children, adolescents and adults
BEHAVIORAL	placebo	no intervention, only follow up

Timeline

• Start date: 2010-01-01
• Primary completion: 2015-12-01
• Completion: 2016-01-01
• First posted: 2009-02-25
• Last updated: 2018-01-17

Locations

1 site across 1 country: Germany