Trials / Completed
CompletedNCT00837889
Cognitive Impairment in Patients With Heart Failure
Cognitive Impairment and Prognosis in Patients With Decompensated Heart Failure
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 60 (actual)
- Sponsor
- Universität des Saarlandes · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
The aim of the present study is threefold: investigating 1) specific cognitive impairments in patients with congestive heart failure, 2) whether cognitive impairments in patients with decompensated heart failure improve after medical recompensation and 3) whether cognitive functioning is related to the long-term prognosis (mortality, rehospitalisation) of those patients.
Detailed description
The daily routine in clinical settings often shows cognitive impairments in patients with congestive heart failure. Recent studies reported declines in cognitive functioning such as executive functions, episodic memory, perceptual speed and attention. However, less is known regarding the differential impairments of cognitive functioning in patients with decompensated heart failure. Study objectives: 1. Identifying specific cognitive impairments in patients with congestive heart failure compared to healthy controls 2. Evaluating the influence of acute decompensation in congestive heart failure on cognitive functioning 3. Investigating the effects of medical treatment on cognitive functioning in patients with decompensated heart failure 4. Exploring long-term effects of cognitive and physiological status on hospitalisation and/or mortality Study design: Cognitive functions of patients with decompensated heart (NYHA III-IV) failure are compared to age and gender matched patients with congestive heart failure (NYHA III-IV) without symptoms of cardiac decompensation and with healthy controls. Decompensated patients are tested before and after medical recompensation. For matched patients and controls, the pretest-posttest timing is based on the recompensation time of the respective patient with decompensated heart failure. The neuropsychological test battery includes measures of episodic memory, working memory, short-term memory, executive functions, perceptual speed and intelligence. In addition, the study applied standardized questionnaires of self assessed quality of life and depression. Relevant physiological data, such as left ventricular systolic function and N-terminal pro brain natriuretic peptide (NT-pro-BNP), are recorded.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | diuretics, inotropica |
Timeline
- Start date
- 2009-01-01
- Primary completion
- 2010-11-01
- Completion
- 2011-05-01
- First posted
- 2009-02-06
- Last updated
- 2025-08-11
Locations
2 sites across 1 country: Germany
Source: ClinicalTrials.gov record NCT00837889. Inclusion in this directory is not an endorsement.