NCT00832442

Collaborative Systematic Overview of Randomised Controlled Trials of Beta-Blockers in the Treatment of Heart Failure

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 18,240 (estimated)
• Sponsor: Royal Brompton & Harefield NHS Foundation Trust · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Several large trials have shown that beta-blocker treatment reduces the risk of death and hospital admission in patients with symptomatic heart failure. Unfortunately, survey data suggests relatively poor utilisation of beta-blockers, despite ample evidence for good tolerability. Additionally there are several important unanswered questions, such as clinical efficacy for specific sub-populations (women, the elderly and patients with diabetes or other co-morbidities) and the effect of beta-blockers in combination with other medications. Previous meta-analyses, based on published tabular data, have been conducted although this approach has important biases and limitations. We plan to perform a carefully conducted systematic review of individual patient data from the major randomised trials of beta-blockers in heart failure. The goals of this collaborative project are to clarify the overall efficacy of beta-blockers and identify sub-groups that show particular benefit, thereby increasing the use of beta-blockers, reducing adverse clinical outcomes and the high costs associated with this condition.

Conditions

• Heart Failure

Interventions

Type	Name	Description
DRUG	Beta blocker	as determined by individual study
OTHER	Placebo	in addition to usual care

Timeline

• Start date: 2008-08-01
• Primary completion: 2012-12-01
• Completion: 2012-12-01
• First posted: 2009-01-30
• Last updated: 2012-05-09

Locations

2 sites across 1 country: United Kingdom