NCT00831337

Evaluation of Probiotics in the Treatment of Portal Hypertension

The Study of Probiotics in Liver Cirrhosis Patients With Portal Hypertension.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 33 (actual)
• Sponsor: Pomeranian Medical University Szczecin · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Accepted

Summary

This study is to evaluate the role of probiotics in the treatment of portal hypertension. In particular the role of probiotics on gut microbiota in liver cirrhosis patients will be studied and compared with cytokines and other substances implicated in the pathogenesis of portal hypertension. The hypothesis whether probiotics may change the prognosis of patients with portal hypertension will be studied. The hypothesis whether probiotics may halt the pathologic cascade of events leading to various complications (e.g. hepato-renal syndrome, spontaneous bacterial peritonitis, bleeding varices) will be reviewed.

Detailed description

Studied probiotics: VSL3

Conditions

• Liver Cirrhosis
• Portal Hypertension
• Encephalopathy

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	VSL3	2 times daily 450 billion live bacteria (in each saschet)

Timeline

• Start date: 2007-04-01
• Primary completion: 2010-11-01
• Completion: 2011-02-01
• First posted: 2009-01-28
• Last updated: 2016-11-23

Locations

1 site across 1 country: Poland