Trials / Completed
CompletedNCT00823277
Metabolic Syndrome and Gen-polymorphs Influence on Weightloss Among Children in Treatment for Overweight
Indicators for the Metabolic Syndrome as Well as the Influence of Different Gen-polymorphs on Weightloss and the Maintenance of Lower Weight Among Children in Treatment for Overweight
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 517 (actual)
- Sponsor
- Holbaek Sygehus · Academic / Other
- Sex
- All
- Age
- 5 Years – 20 Years
- Healthy volunteers
- Accepted
Summary
Definition: the overall objective is to examine childhood obesity with focus on NAFLD and its treatment. Further, we aimed to investigate the impact of genetic variation on obesity. The specific aims are to; * describe the degree of NAFLD among overweight and obese, Danish children. (hypothesis; the degree for pediatric NAFLD among Danish Children was equal that found in other Caucasian paediatric study populations). * investigate the effect of a multidisciplinary intervention treatment of 1 year on liver fat content. (hypothesis; the intervention could reduce the liver fat percentage and a reduction in BMI SDS would associate with a reduction in liver fat content) - Analyze changes in liver fat content in relation to changes in levels of fasting blood variables to see if any of them could be used as a clinical tool for monitoring hepatic steatosis in the clinic. (hypothesis; serum aminotransferases (separately and their ratio, respectively), serum insulin, and HOMA-IR could predict improvement in liver fat content \- Investigate the association between genetic variants and obesity.
Conditions
- Childhood Obesity
- NAFLD (Non-alcoholic Fatty Liver Disease)
- Hypertension
- Hyperlipidemia
- Insulin Sensitivity
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Chronic care multidisciplinary intervention of childhood obesity | Overweight and obese Children, 5-20 Years old, followed by Paediatricians and other Health Personals (multidisciplinary team). Included at their first visit in the clinic (baseline)and follow-up after \~ 1 Year. |
Timeline
- Start date
- 2009-01-01
- Primary completion
- 2012-08-01
- Completion
- 2012-08-01
- First posted
- 2009-01-15
- Last updated
- 2023-07-17
Locations
1 site across 1 country: Denmark
Source: ClinicalTrials.gov record NCT00823277. Inclusion in this directory is not an endorsement.