NCT00809744

Vitamin D AND Glucose Handling Evaluated by Glucose Clamp

Vitamin D AND Cardiovascular Disease

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 160 (actual)
• Sponsor: University Hospital of North Norway · Academic / Other
• Sex: All
• Age: 30 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

In this study the investigators want to compare glucose handling (insulin secretion and insulin sensitivity) in 100 persons with low and 50 persons with normal-high levels of vitamin D, using a hyperglycemic clamp technique, were sugar is given intravenously for 3 hours in order to keep the blood sugar level at 10 mmol/L. Those with low vitamin D levels will be randomized to treatment with vitamin D3 (cholecalciferol) 40 000 IU/week or placebo for 6 months before a new clamp is performed. The study hypothesis is that persons with low vitamin D levels have impaired glucose handling which might be improved by vitamin D supplementation.

Conditions

• Insulin Sensitivity
• Intraocular Pressure

Interventions

Type	Name	Description
DRUG	cholecalciferol	capsules, 20 000IU, twice a week, 6 months duration

Timeline

• Start date: 2008-11-01
• Primary completion: 2010-12-01
• Completion: 2010-12-01
• First posted: 2008-12-17
• Last updated: 2011-11-03

Locations

1 site across 1 country: Norway