Trials / Unknown
UnknownNCT00808535
Cardiac Magnetic Resonance Imaging for Detecting Endothelial Dysfunction
A Pilot Study of Cardiac Magnetic Resonance Imaging For Detection of Myocardial Perfusion Abnormalities in Endothelial Dysfunction
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 60 (estimated)
- Sponsor
- University of California, Los Angeles · Academic / Other
- Sex
- All
- Age
- 18 Years – 50 Years
- Healthy volunteers
- Accepted
Summary
The goal of this research study is to demonstrate that Cardiac Perfusion MRI with Vasomotor Stress may serve as a non-invasive and less risky imaging technique for detecting non-obstructive perfusion deficits and/or abnormalities in myocardial blood flow (MBF) in patients with endothelial dysfunction. This is a controlled study, which will enroll approximately 60 subjects (30 diabetics and 30 non-diabetics to serve as healthy controls), and will include male and non-pregnant females, between the ages 18-50 years. All eligible participants will sign an informed consent and will complete a Lifestyle Questionnaire. They will undergo blood work which includes: * 2-hour Oral Glucose Tolerance Test and Fasting Labs for Glucose, Insulin, C-Peptide, HbA1c, Creatinine, and Lipid Panel. * Urine Albumin to Creatinine ratio for microalbuminuria. * Serum inflammatory markers: E-selectin, homocysteine, ADMA, VCAM, IL-6, TNFalpha, hs-CRP and PAI-1. After blood work, all participants will undergo cardiac MR perfusion imaging procedure with Cold Pressor Test and Adenosine Stress Test.
Conditions
- Endothelial Dysfunction
- Myocardial Perfusion Abnormalities
- Cardiac MRI Perfusion With Vasomotor Stress
- Diabetes
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Cardiac Perfusion MRI w Vasomotor Stress | All participants will undergo Cardiac Perfusion MRI with Vasomotor Stress. Vasomotor Stress will include both Cold Pressor Test and Adenosine Stress Test. |
Timeline
- Start date
- 2009-02-01
- Primary completion
- 2010-02-01
- Completion
- 2010-03-01
- First posted
- 2008-12-16
- Last updated
- 2009-02-09
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT00808535. Inclusion in this directory is not an endorsement.