NCT00800722

A Randomized Trial to Study Combined Pulsed Dye Laser and Rapamycin Treatment of Port Wine Stain Birthmarks.

Phase I Combined Use of Pulsed Dye Laser and Rapamycin

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 21 (actual)
• Sponsor: University of California, Irvine · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to improve port wine stain therapeutic outcome in response to laser therapy. The researchers want to determine whether the combined use of pulsed dye laser therapy and rapamycin will improve PWS therapeutic outcome.

Detailed description

The researchers want to combined use of pulsed dye laser to induce port wine stain blood vessel injury, and rapamycin directly inhibits the proliferation of vascular endothelial cells driven by vascular endothelial growth factor which preventing port wine stain angiogenesis and recanalization, to improve port wine stain lesion blanching.

Conditions

• Port Wine Stain

Interventions

Type	Name	Description
DRUG	Rapamycin Treatment of Port Wine Stain	Treatment of Port Wine Stain

Timeline

• Start date: 2008-11-01
• Primary completion: 2014-06-01
• Completion: 2014-06-01
• First posted: 2008-12-02
• Last updated: 2022-11-01

Locations

1 site across 1 country: United States