NCT00800540

Circadian Ocular Perfusion Pressure and Ocular Blood Flow

Effects of Topical Hypotensive Drugs on Circadian Ocular Perfusion Pressure and Ocular Blood Flow in Patients With Open-Angle Glaucoma

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 35 (actual)
• Sponsor: Alcon Research · Industry
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study was to compare the short term effects of two intraocular pressure (IOP) lowering medications on ocular perfusion pressure (OPP), ocular blood flow, intraocular pressure, and blood pressure in patients with glaucoma. Ocular perfusion pressure (OPP) is defined as the difference between arterial blood pressure (diastolic and systolic) and intraocular pressure. The primary efficacy assessment is based on diastolic ocular perfusion pressure.

Conditions

• Glaucoma

Interventions

Type	Name	Description
DRUG	Brinzolamide 10 mg/ml/Timolol 5 mg/ml eye drops suspension	Fixed combination ophthalmic suspension
DRUG	Brimonidine 20 mg/ml/Timolol 5 mg/ml eye drops solution	Fixed combination ophthalmic solution

Timeline

• Start date: 2009-02-01
• Primary completion: 2012-01-01
• Completion: 2012-01-01
• First posted: 2008-12-02
• Last updated: 2013-03-22
• Results posted: 2013-03-22

Locations

1 site across 1 country: United States