NCT00781131

Trial of Pregabalin for Post-operative Pain in Women Undergoing Abdominal Hysterectomy

A Randomized, Placebo Controlled Trial of Pregabalin for Post-operative Pain in Women Undergoing Abdominal Hysterectomy

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 101 (actual)
• Sponsor: IWK Health Centre · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

We hypothesize that pregabalin will decrease post-operative pain scores and opioid use following abdominal hysterectomy compared to placebo. This study has been designed to determine if after an abdominal hysterectomy, the addition of pregabalin to their peri-operative analgesia regimen will demonstrate superior analgesia compared to placebo in terms of lower pain scores and reduced usage of opioids. The primary outcome will be post-operative pain, measured by total opioid consumption. Do women undergoing an abdominal hysterectomy with general anesthesia and receiving pregabalin prior to their surgery and 12 hours later have lower opioid consumption in the first 24 hours after their surgery than those women who received placebo?

Conditions

• Postoperative Pain
• Opioid Use

Interventions

Type	Name	Description
DRUG	Pregabalin	pregabalin 75 or 150 mg
DRUG	Placebo	lactulose placebo

Timeline

• Start date: 2008-05-01
• Primary completion: 2010-07-01
• Completion: 2011-01-01
• First posted: 2008-10-28
• Last updated: 2013-05-23

Locations

1 site across 1 country: Canada