NCT00779467

Epidural Neostigmine for Labor Pain

Epidural Neostigmine Dose Response for the Treatment of Labor Pain

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 200 (actual)
• Sponsor: Wake Forest University · Academic / Other
• Sex: Female
• Age: 18 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to see which dose of epidural neostigmine is the best additive to use with the numbing medication used in an epidural during labor.

Detailed description

This study is examining the use of the non-narcotic medication, neostigmine, in combination with the local anesthetic bupivacaine when compared with the commonly used narcotic fentanyl in providing pain relief with the fewest side effects in labor analgesia.

Conditions

• Labor Pain

Interventions

Type	Name	Description
DRUG	Neostigmine	utilizing 3 different dosages of neostigmine and comparing it to the standard of fentanyl. Infusion runs via PCA throughout labor analgesia.
DRUG	Bupivacaine
DRUG	fentanyl	fentanyl 2 mcg/ml

Timeline

• Start date: 2008-10-01
• Primary completion: 2013-11-01
• Completion: 2013-11-01
• First posted: 2008-10-24
• Last updated: 2018-09-11
• Results posted: 2017-04-10

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study