NCT00775099

Combustion Derived Air Pollution and Vascular Function

The Effects of Combustion-Derived Air Pollution on Vascular Vasomotor and Fibrinolytic Function in Healthy Volunteers (Diesel Exposure)

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 16 (actual)
• Sponsor: University of Edinburgh · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

Air pollution is a major cause of cardiovascular morbidity and mortality. The components of air pollution responsible and the mechanisms through which they might mediate these harmful effects remain only partially understood. The link between cardiovascular disease and air pollution is strongest for fine particulate matter. Fine particulate matter (PM) is produced from the combustion of fossil fuels with the most significant threat thought to be posed by small particles less than 10µm (PM 10) which can be inhaled into the lungs. We propose to identify the precise component of diesel exhaust that mediates the adverse cardiovascular effects using a carbon particle generator, and a particle concentrator. The aim of this study proposal is to assess the vascular effects of different types and components of air pollution in healthy subjects. We intend to test the hypotheses that: 1. Combustion derived nanoparticulate causes an acute impairment of endothelial vasomotor and fibrinolytic function in healthy volunteers. 2. Exposure to combustion derived air pollution is associated with increased thrombus formation.

Conditions

• Endothelial Dysfunction

Interventions

Type	Name	Description
PROCEDURE	Forearm Vascular Study	Forearm venous occlusion plethysmography to measure forearm blood flow during intra-arterial infusion of the vasodilators Verapamil (10-100 µg/min), bradykinin (100-1000 pmol/min), sodium nitroprusside (2-8 µg/min) and Acetylcholine (5-20 mg/min).
PROCEDURE	Badimon Chamber	Ex-vivo assessment of thrombus formation using Badimon Chamber

Timeline

• Start date: 2005-09-01
• Primary completion: 2006-03-01
• Completion: 2006-03-01
• First posted: 2008-10-17
• Last updated: 2008-10-17

Locations

1 site across 1 country: United Kingdom