NCT00742066

Role of AT1-receptor Blockers in Insulin-induced Vasodilation.

Insulin-induced Microvascular Activity in Patients With Essential Hypertension: a Possible Role for Angiotensin II AT1-receptor Blockers.

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 32 (estimated)
• Sponsor: Maastricht University Medical Center · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

In this study we hypothesize that blocking the angiotensin II AT1-receptor improves the insulin-induced microvascular dilatation. Objectives: 1. Does blockade of the angiotensin II AT1-receptor improve the insulin-induced microvascular effects in hypertensive patients. 2. Does blockade of the angiotensin II AT1-receptor impair the insulin-induced microvascular effects in normotensive control subjects?

Conditions

• Hypertension
• Insulin Resistance
• Microcirculation

Interventions

Type	Name	Description
DRUG	Irbesartan	Single dose 600mg orally
DRUG	Felodipine	single dose 10mg Felodipine ER
DRUG	Placebo	Single dose tablet orally

Timeline

• Start date: 2008-03-01
• Primary completion: 2009-07-01
• Completion: 2009-07-01
• First posted: 2008-08-27
• Last updated: 2011-03-17

Locations

1 site across 1 country: Netherlands