NCT00741312

Influence of Physical Exercise on Endothelial Function in Pregnant Women

Influence of Physical Exercise on Endothelial Function in Pregnant Women: Randomized Clinical Trial

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 64 (estimated)
• Sponsor: Universidad del Valle, Colombia · Academic / Other
• Sex: Female
• Age: 16 Years – 30 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine the effect of regular aerobic exercise on endothelial function in pregnancy.

Detailed description

Preeclampsia is a common maternal disease that complicates 5% to 10% of pregnancies and remains as the major cause of maternal and neonatal mortality, especially in developing countries. Cost-effective interventions aimed to prevent the development of preeclampsia are urgently needed. Ethiopathogenesis of preeclampsia involves multiple mechanisms as oxidative stress, endothelial dysfunction, infections, maternal constitutional factors, and others. Regular aerobic exercise recovers endothelial function, decreases oxidative stress and improves maternal constitutional factors. The purpose of this Controlled Clinical Trial is to determine the effect of regular aerobic exercise on endothelium-dependent brachial artery flow-mediated dilatation. Furthermore, the effect of exercise on biomarkers on vascular function and perinatal outcomes will be evaluated.

Conditions

• Pregnancy
• Preeclampsia
• Exercise

Interventions

Type	Name	Description
BEHAVIORAL	Regular aerobic physical exercise	Walking (10 minutes), aerobic exercise (30 minutes), stretching (10 minutes) and relaxation exercise (10 minutes). Exercise will be performed at three sessions per week. All sessions will be supervised by a physical therapist and a physical educator. The exercise-program follows the ACOG and ACSM exercise prescription. Aerobic activities will be performed at moderate intensity (60-70% of maximal heart rate) measured by the 6-20 Borg's rating scale. Each session starts with a 5 minutes of warm up, followed by 30 minutes of aerobic activity, including 5 minutes cool down. This is followed by 15 minutes of circuit strength training of the upper limbs, lower limbs, and deep abdominal stabilization muscles. The last 5 minutes consists of stretching and relaxation exercises.
BEHAVIORAL	Activities of daily living	Basic activities of daily living (bathing, dressing, eating, walking) without counseling by a physical therapist.

Timeline

• Start date: 2008-10-01
• Primary completion: 2010-10-01
• Completion: 2011-01-01
• First posted: 2008-08-26
• Last updated: 2011-01-21

Locations

1 site across 1 country: Colombia