NCT00729300

A Study of the Relationship Between Disulfiram and Cocaine Self-administration.

Laboratory Models of Cocaine Self-administration

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 52 (actual)
• Sponsor: Baylor College of Medicine · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Not accepted

Summary

The problem of cocaine dependence remains a major medical, social, and legal concern. Several studies have suggested that disulfiram may be beneficial for the treatment of cocaine dependence. A common assumption has been that disulfiram treatment, by increasing DA availability, enhances the aversive aspects of stimulants. This study aims to measure plasma activity in those with the C/C DBH genotype, which is associated with higher DBH activity subsequently making the disulfiram treatment more effective, as well as determine the effects of treatment with disulfiram on cocaine self-administration using a human laboratory model of cocaine self-administration.

Conditions

• Cocaine Addiction

Interventions

Type	Name	Description
DRUG	placebo	0mg daily
DRUG	disulfiram	250mg daily

Timeline

• Start date: 2006-04-01
• Primary completion: 2016-06-01
• Completion: 2016-06-01
• First posted: 2008-08-07
• Last updated: 2023-07-19
• Results posted: 2023-07-19

Locations

1 site across 1 country: United States