NCT00719290

Primary Angle Closure Glaucoma and Aqueous Dynamics

A Randomised Comparative Study of the Effects of Cataract Extraction With Lens Implant Alone Versus Cataract Extraction With Lens Implant and Goniosynechialysis on Outflow Facility in Patients With Primary Angle Closure Glaucoma.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: Guy's and St Thomas' NHS Foundation Trust · Academic / Other
• Sex: All
• Age: 21 Years
• Healthy volunteers: Not accepted

Summary

The aim of the study is to determine which is the best treatment for people with cataract and primary angle closure (PAC).In PAC, apposition of the iris tissue to the drainage channels (Trabecular Meshwork-TM) of the eye results in damage and formation of adherences between these structures (Peripheral anterior synaechiae-PAS) causing a mechanical obstruction of the aqueous outflow via the TM. It is thought that cataract surgery combined with mechanical separation of the iris from the TM with the breakage of PAS(we call this separation 'goniosynechialysis') would make the pressure even lower as it would cause the drain to open to a greater extent than cataract surgery alone. This technique is not new, and the results have been very encouraging. Comparing this technique to cataract surgery alone however, has not been done and this is exactly what we would like to do in order to help us decide what is the best treatment. In summary, the investigators propose that cataract surgery with goniosynechialysis would lower intraocular pressure to a greater extent than cataract surgery alone in patients with significant PAS.

Conditions

• Primary Angle Closure

Interventions

Type	Name	Description
PROCEDURE	Phacoemulsification (Acrylic Foldable Intraocular Lens (Acrysoft)), (Healon5)	Phacoemulsification of the lens with intraocular lens implant
PROCEDURE	Phacoemulsification and goniosynechialysis (Acrylic Foldable Intraocular Lens (Acrysoft)), (Healon5)	Phacoemulsification of the lens with intraocular lens implant and goniosynechialysis

Timeline

• Start date: 2008-07-01
• Primary completion: 2015-08-01
• Completion: 2015-08-01
• First posted: 2008-07-21
• Last updated: 2015-08-19

Locations

1 site across 1 country: United Kingdom