NCT00708994

Cannabinoids, Neural Synchrony, and Information Processing

Cannabinoids, Psychosis, Neural Synchrony, and Information Processing

• Status: Completed
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 42 (actual)
• Sponsor: Yale University · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Accepted

Summary

The study examines the effects of delta-9-tetrahydrocannabinol (Δ9-THC), the principal active ingredient of cannabis, on neural synchrony. Neural synchrony is studied using electroencephalography (EEG).

Conditions

• Cannabis
• Psychotic Disorders

Interventions

Type	Name	Description
DRUG	THC	* Very low dose (0.0015 mg/kg = 0.21 mg in a 70kg individual) THC, dissolved in alcohol. Administered intravenously over 10 minutes. * Low dose (0.015 mg/kg = 1.05 mg in a 70kg individual) THC, dissolved in alcohol. This dose is roughly equivalent to smoking approximately 1/4th of a marijuana cigarette, or "joint". Administered intravenously over 10 minutes. * Medium dose (0.03 mg/kg = 2.1 mg in a 70 kg individual) THC, dissolved in alcohol. This dose is roughly equivalent to smoking approximately 1/2 of a marijuana cigarette, or "joint". Administered intravenously over 10 minutes.
DRUG	Placebo	• Control: small amount of alcohol intravenous (quarter teaspoon), with no THC over 10 minutes

Timeline

• Start date: 2008-02-25
• Primary completion: 2012-12-03
• Completion: 2012-12-03
• First posted: 2008-07-03
• Last updated: 2022-03-09

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study