NCT00708097

In Situ Caries Efficacy of Fluoride Toothpastes

Clinical Efficacy of Fluoride Toothpastes Using an in Situ Caries Model

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 57 (actual)
• Sponsor: GlaxoSmithKline · Industry
• Sex: All
• Age: 18 Years – 78 Years
• Healthy volunteers: Accepted

Summary

This study is to evaluate the effect of fluoride dentifrices on enamel with artificial caries lesions in an in situ model

Detailed description

In situ models represent an acceptable approach for testing the anti-caries potential of fluoride products. This study is to evaluate the effect of fluoride dentifrice containing 1450 parts per million fluoride (ppm F) on enamel with artificial caries lesions in an in situ model. The study toothpaste containing sodium fluoride (NaF) and 0.4% carbopol will be compared to 4 other dentifrices. Comparator toothpastes include NaF toothpaste (1400 ppm F), NaF toothpaste (675 ppm F), sodium monofluorophosphate (NaMFP) and NaF toothpaste (1450 ppm F) and placebo toothpaste (0 ppm F).

Conditions

• Caries

Interventions

Type	Name	Description
DRUG	NaF	Fluoride
DRUG	Placebo	Placebo
DRUG	NaMFP	Fluoride

Timeline

• Start date: 2008-04-01
• Primary completion: 2008-07-01
• Completion: 2008-07-01
• First posted: 2008-07-02
• Last updated: 2015-01-01
• Results posted: 2013-06-24

Locations

1 site across 1 country: United States