NCT00701896

Smoking Cessation Using Motivational Therapy and Varenicline

Smoking Cessation and the Natural History of HIV-Associated Emphysema

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 294 (actual)
• Sponsor: Philip Diaz · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

People that are infected with HIV appear to be especially susceptible to the adverse effects of cigarette smoking. The purpose of this study is to determine if quitting smoking by using a specialized smoking cessation treatment can prevent one from developing accelerated lung damage, particularly emphysema.

Detailed description

HIV-infected smokers are at increased risk for life-threatening diseases, such as pneumonia. To date, very little is known about the tobacco consumption characteristics of this at-risk population of smokers, but it has been well documented that they are at high risk for smoking-related co-morbidities. In addition, few effective cessation strategies have been described in HIV-infected populations. A specialized smoking cessation that combines recommendations from an existing scientifically-valid clinical guideline with Motivational Interviewing a new pharmacotherapeutic agent, may be an effective mechanism to apply to this vulnerable population of smokers. This initial, efficacy investigation has the potential to guide future treatment and research pertaining to tobacco cessation, respiratory illness and HIV.

Conditions

• Smoking
• HIV Infections

Interventions

Type	Name	Description
DRUG	Varenicline tartrate	1 mMg tablet form; daily during week 1 (pre-quit week) followed by 1 mg twice daily for weeks 2-12.
DRUG	Nicotine Replacement Therapy	Nicotine gum and nicotine patch
OTHER	Biological Control	No treatment intervention only information and procedures.
BEHAVIORAL	Motivational Interview	60 minute one-on-one Interview

Timeline

• Start date: 2008-10-03
• Primary completion: 2013-04-20
• Completion: 2013-06-20
• First posted: 2008-06-19
• Last updated: 2021-01-15
• Results posted: 2021-01-15

Locations

1 site across 1 country: United States