NCT00699946

Prophylactic Olanzapine Versus Placebo for Prevention of Postoperative Delirium After Joint Replacement Surgery

A Double-Blind, Randomized, Placebo-Controlled Study of Perioperative Administration of Olanzapine to Prevent Postoperative Delirium in Joint Replacement Patients

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 495 (actual)
• Sponsor: The New England Baptist Hospital · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Accepted

Summary

In this study we wanted to determine if perioperative administration of olanzapine prior to knee or hip replacement surgery in high risk patients would prevent the onset of postoperative delirium.

Detailed description

Postoperative delirium is a serious and common (20% to 60%) complication in orthopedic surgery patients. In this study we investigate whether prophylactic administration of olanzapine can prevent delirium from occurring after knee or hip replacement in high-risk patients \> 65 years of age. This is a randomized, double-blind, single center, placebo-controlled study.

Conditions

• Delirium

Interventions

Type	Name	Description
DRUG	olanzapine	5 mg preoperative and 5mg postoperative prior to discharge to inpatient nursing floor
DRUG	placebo	placebo administered preoperatively and postoperatively prior to discharge to inpatient nursing floor

Timeline

• Start date: 2005-01-01
• Primary completion: 2007-08-01
• Completion: 2007-10-01
• First posted: 2008-06-18
• Last updated: 2009-01-21

Locations

1 site across 1 country: United States