NCT00687128

Exercise Dose-Response on Features of the Metabolic Syndrome

Dose-Response Effects of Aerobic Exercise on Insulin Sensitivity and the Metabolic Syndrome

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 93 (actual)
• Sponsor: Charles Drew University of Medicine and Science · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

This study investigates the degree of improvement in insulin resistance and features of the metabolic syndrome in non-diabetic overweight or obese subjects after training in a low-intensity, moderate-intensity or non-aerobic exercise program, as well as self-initiated exercise behavior after the assigned exercise program.

Detailed description

The proposed study is a randomized, open study comparing low-intensity and moderate-intensity aerobic exercise versus non-aerobic (stretching) exercise on direct measurements of insulin resistance and variables associated with the metabolic syndrome. This 6-month intervention will be followed by an additional 6-month follow-up period during which subjects will be encouraged to maintain their exercise regimen (along with their prescribed diet) but without scheduled supervision. Behavioral variables associated with adherence will be analyzed along with changes in the above physiological variables.

Conditions

• Insulin Resistance
• Metabolic Syndrome
• Obesity

Interventions

Type	Name	Description
BEHAVIORAL	Low-intensity treadmill exercise	Treadmill walking at 30% of VO2Reserve, 3-5 times per week at 20-60 minutes per session, progressive.
BEHAVIORAL	Moderate-intensity treadmill exercise	Treadmill walking at 60% of VO2Reserve, 3-5 times per week at 20-60 minutes per session, progressive.
BEHAVIORAL	Non-aerobic stretching exercise	Floor stretching exercise, 3-5 times per week at 20-60 minutes duration per session, progressive.

Timeline

• Start date: 2004-10-01
• Primary completion: 2009-09-01
• Completion: 2010-04-01
• First posted: 2008-05-30
• Last updated: 2012-02-28

Locations

1 site across 1 country: United States