NCT00683982

Use of Nitazoxanide and Probiotics in Acute Diarrhea Secondary to Rotavirus

Nitazoxanide vs Probiotics in the Treatment of Acute Rotavirus Diarrhea in Children: A Randomized Single Blind Controlled Trial in Bolivian Children

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 75 (actual)
• Sponsor: Centro Pediatrico Albina de Patino · Academic / Other
• Sex: All
• Age: 28 Days – 24 Months
• Healthy volunteers: Not accepted

Summary

Nitazoxanide has proved an cytoprotective effect against rotavirus infection. How it could be clinically important in time of hospitalization and reduction of duration of diarrhea secondary to rotavirus?

Detailed description

Nitazoxanide has demonstrated a cytoprotective effect against rotavirus, reducing duration time of diarrhea in comparison to placebo in previous studies. In the current study, based in those results, we design a randomized single-blind controlled trial, in order to asses the effectiveness of nitazoxanide and probiotics in comparison with a control group

Conditions

• Diarrhea
• Rotavirus Infection

Interventions

Type	Name	Description
DRUG	Nitazoxanide	Nitazoxanide 15mg/Kg/day twice day for 3 days
DRUG	Probiotic mix preparation	Probiotic preparation 1 gram twice a day for 5 days
OTHER	Oral hydration solutions	Oral hydration solutions as needed

Timeline

• Start date: 2007-08-01
• Primary completion: 2008-05-01
• Completion: 2008-05-01
• First posted: 2008-05-26
• Last updated: 2008-05-26

Locations

1 site across 1 country: Bolivia