NCT00683774

Insulin and Polycystic Ovary Syndrome

Determination if Direct Inhibition of Insulin Release With Diazoxide Decreases Renal Clearance of D-Chiroinositol (DCI) and Increases Circulating DCI in Obese Women With Polycystic Ovary Syndrome (PCOS)

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 21 (actual)
• Sponsor: Virginia Commonwealth University · Academic / Other
• Sex: Female
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

Increased insulin levels leads to increased secretion of D-chiro inositol(DCI) from the kidneys in women with PCOS, but not in normal women. This leads to a reduction in circulating DCI and insulin stimulated release of DCI-IPG.To determine if decreasing circulating insulin directly by inhibition of islet insulin release with diazoxide in obese women with PCOS 1)decreases the renal clearance of DCI and 2) increases the circulating concentration of DCI.

Conditions

• PCOS

Interventions

Type	Name	Description
DRUG	diazoxide	100mg orally three times per day for 10 days

Timeline

• Start date: 2005-11-01
• Primary completion: 2008-12-01
• Completion: 2008-12-01
• First posted: 2008-05-23
• Last updated: 2017-06-14
• Results posted: 2014-08-21

Locations

1 site across 1 country: United States