Trials / Completed
CompletedNCT00683202
Low-Dose Aspirin in in Vitro Fertilization (IVF) and Intracytoplasmic Sperm Injection (ICSI) Treatments
The Significance of Low-Dose Aspirin on Ovarian Responsiveness, Uterine Hemodynamics and Pregnancy Outcome in in Vitro Fertilization and in Intracytoplasmic Sperm Injection: A Randomized, Placebo-Controlled Double-Blind Study
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 374 (actual)
- Sponsor
- University of Oulu · Academic / Other
- Sex
- Female
- Age
- 18 Years – 39 Years
- Healthy volunteers
- Not accepted
Summary
In this study we hypothesized that low-dose aspirin therapy (100 mg daily) improves ovarian responsiveness, uterine haemodynamics and clinical pregnancy rates in unselected subjects undergoing IVF/ICSI when the treatment is started concomitantly with controlled ovarian hyperstimulation.
Detailed description
Low-dose acetylsalicylic acid irreversibly inhibits the cyclo-oxygenase enzyme in platelets, thus preventing the synthesis of thromboxane, which causes vasoconstriction and platelet aggregation. By this mechanism low-dose aspirin may enhance ovarian and uterine blood flow and tissue perfusion and thus improve ovarian responsiveness for gonadotrophins and endometrial receptivity for implantation. Randomized controlled studies and meta-analyses on the low-dose aspirin therapy to improve IVF/ICSI outcome or uterine hemodynamics have revealed conflicting results.
Conditions
- Pregnancy
- Miscarriage Less Than 12 Gestational Weeks
- Extrauterine Pregnancy
- Preeclampsia
- Intrauterine Fetal Growth Restriction
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Acetylsalicylic acid | Acetylsalicylic acid 100 mg or placebo daily perorally started on the first day of ovarian gonadotrophin stimulation in in vitro fertilization or in intracytoplasmic sperm injection |
| DRUG | Placebo | Acetylsalicylic acid 100 mg or placebo daily perorally started on the first day of ovarian gonadotrophin stimulation in in vitro fertilization or in intracytoplasmic sperm injection |
Timeline
- Start date
- 2001-03-01
- Primary completion
- 2006-03-01
- Completion
- 2006-03-01
- First posted
- 2008-05-23
- Last updated
- 2008-05-23
Locations
1 site across 1 country: Finland
Source: ClinicalTrials.gov record NCT00683202. Inclusion in this directory is not an endorsement.