NCT00682734

Metoclopramide for Migraine: A Dose Finding Study

Metoclopramide for Acute Migraine: A Dose Finding Study

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 349 (actual)
• Sponsor: Montefiore Medical Center · Academic / Other
• Sex: All
• Age: 18 Years – 69 Years
• Healthy volunteers: Not accepted

Summary

Metoclopramide is an effective intravenous treatment for acute migraine attacks, but we do not know the best dose to administer. This study compares three different doses of metoclorpamide.

Detailed description

Patients with acute migraine attacks are eligible for enrollment if they present to the emergency department of Montefiore Medical Center. Pain scores are assessed at baseline and every 30 minutes for two hours, and then again by telephone 48 hours after discharge

Conditions

• Migraine

Interventions

Type	Name	Description
DRUG	metoclopramide	metoclopramide 20 mg
DRUG	metoclopramide	metoclopramide 40 mg
DRUG	metoclopramide	metoclopramide 10 mg
DRUG	Diphenhydramine 25mg	Diphenhydramine 25mg, administered as an intravenous drip over 20 minutes

Timeline

• Start date: 2008-04-01
• Primary completion: 2010-03-01
• Completion: 2010-03-01
• First posted: 2008-05-22
• Last updated: 2018-05-31
• Results posted: 2012-12-31

Locations

1 site across 1 country: United States