NCT00682357

Effect of Intraarticular Steroids on Bone Turnover in Osteoarthritis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 25 (actual)
• Sponsor: University of Kansas Medical Center · Academic / Other
• Sex: All
• Age: 40 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

Oral and nasal steroids may enhance osteoporosis by suppressing bone formation. Intra-articular steroids may also suppress bone formation, however, the duration or relationship to a steroid dose has not been established. It is hypothesized that intra-articular steroids suppress bone formation transiently, returning to pretreatment levels within four weeks in subjects with osteoarthritis.

Detailed description

Oral and nasal steroids may enhance osteoporosis by suppressing bone formation. Intra-articular steroids may also suppress bone formation, however, the duration or relationship to a steroid dose has not been established. It is hypothesized that intra-articular steroids suppress bone formation transiently, returning to pretreatment levels within four weeks in subjects with osteoarthritis. The purpose of the study is to determine if intra-articular steroids suppress markers of bone formation or resorption in osteoarthritis patients and whether these markers may be modified by Vitamin D or Dual-energy X-ray absorptiometry (DEXA) bone density status

Conditions

• Osteoarthritis

Interventions

Type	Name	Description
DRUG	Methylprednisolone and Lidocaine	Methylprednisolone 80 mg, intra-articular and lidocaine 20 mg
DRUG	Methylprednisolone and Lidocaine	Methylprednisolone 16 mg intra-articular and lidocaine 20 mg
DRUG	Placebo and Lidocaine	Placebo and lidocaine 20 mg

Timeline

• Start date: 2008-05-01
• Primary completion: 2009-11-01
• Completion: 2010-05-01
• First posted: 2008-05-22
• Last updated: 2024-08-13
• Results posted: 2016-11-29

Locations

1 site across 1 country: United States