NCT00681655

GABRA2 and the Pharmacokinetics of Risk for Alcoholism (GPRA)

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 141 (actual)
• Sponsor: Indiana University · Academic / Other
• Sex: All
• Age: 21 Years – 27 Years
• Healthy volunteers: Accepted

Summary

This study will assess whether the presence of a particular form of a gene, GABRA2, affects the functional responses of the human brain to alcohol administration and will evaluate that relationship in the context of factors known to increase the risk for future alcoholism.

Detailed description

Each subject completed a total of 2 2.8 hr-long clamping sessions.Within each session, procedures differed only by the content of the infusate. In one session, 6% ethanol was infused. In the other session, only vehicle was infused, quantifying the placebo response for every subject. The order of alcohol or placebo sessions was counterbalanced; subjects were blind to which session was which; sessions were scheduled to occur approximately 2 weeks apart. Measures were collected before, and at beginning and end of infusion, and included subjective perceptions, EMG, EEG, stop-signal performance, eye movements, and auditory responses. Design allowed analysis of effect of alcohol vs placebo, initial effect of alcohol and acute tolerance to alcohol.

Conditions

• Alcoholism

Interventions

Type	Name	Description
OTHER	Alcohol	Alcohol (6% in saline vehicle) infused for 2.8 hour long clamping session (Breath alcohol level maintained at 60 mg/dL throughout).
OTHER	Placebo	Placebo (saline vehicle) infused for 2.8 hour long session.

Timeline

• Start date: 2008-05-01
• Primary completion: 2012-04-14
• Completion: 2012-04-14
• First posted: 2008-05-21
• Last updated: 2022-04-07

Locations

1 site across 1 country: United States