NCT00675272

Organ Donation and Hydrocortisone Treatment

Organ Donation and Vasopressor Use: Effects of Hydrocortisone Treatment

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 38 (actual)
• Sponsor: Kuopio University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Brain death patients who are selected for organ donation very often suffer from haemodynamic instability. To treat this, high amounts of vasoactive drugs(norepinephrine) may be needed to raise blood pressure. However,norepinephrine may have negative influence on several organs causing reduced blood flow ischemia. Our hypothesis is that hydrocortisone treatment may reduce the amount of vasoactive drugs needed to keep the blood pressure stable in patients selected for organ donation.

Detailed description

When patients are treated in the ICU only as possible organ donators they will be assessed for eligibility for the study. Iv hydrocortisone or placebo will be administered every 6 hours. Several hormonal samples will be collected.

Conditions

• Brain Death

Interventions

Type	Name	Description
DRUG	hydrocortisone	hydrocortisone 50mg iv. every 6 hours
DRUG	sodium chloride	sodium chloride every 6 hours iv

Timeline

• Start date: 2008-05-01
• Primary completion: 2011-08-01
• Completion: 2011-12-01
• First posted: 2008-05-09
• Last updated: 2015-04-06

Locations

2 sites across 1 country: Finland