NCT00640991

REsearching Coronary REduction by Appropriately Targeting Euglycemia (RECREATE Pilot Study)

An International Multicentre Randomized Controlled Trial of Intensive Insulin Therapy Targeting Normoglycemia In Acute Myocardial Infarction: the RECREATE (REsearching Coronary REduction by Appropriately Targeting Euglycemia) Pilot Study

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 500 (estimated)
• Sponsor: Population Health Research Institute · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Insulin will safely reduce glucose levels in patients with acute ST-elevation myocardial infarction and admission hyperglycemia.

Detailed description

Patients will be randomly assigned to either the control arm and will receive usual AMI care or the experimental arm, which will include routine AMI care as well as intensive therapy intervention. In addition to the capillary blood glucose measurements obtained to titrate insulin doses in the experimental arm patients, laboratory plasma glucose will be drawn in all patients at randomization, 10, 24, 48, and 72 hours post randomization, 7 days post randomization (or hospital discharge if that occurs first), and 30 days post randomization.

Conditions

• Hyperglycemia
• Cardiovascular Diseases
• Myocardial Infarction

Interventions

Type	Name	Description
DRUG	glulisine insulin, glargine insulin	IV infusion of glulisine, SC injection of glargine

Timeline

• Start date: 2008-04-01
• Primary completion: 2010-06-01
• Completion: 2010-06-01
• First posted: 2008-03-21
• Last updated: 2010-06-16

Locations

13 sites across 3 countries: Argentina, Canada, India