NCT00639990

Respiratory Mechanics in Brain Injured Patients

Effects of PEEP in Brain Injury Patients

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Università degli Studi dell'Insubria · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The hypothesis is that brain injury patients have alterations of the respiratory system related to intraabdominal pressure. Furthermore application of moderate levels of PEEP may improve respiratory function in these patients.

Detailed description

We investigate the mechanical properties of the respiratory system, partitioned into its lung and chest wall components, the functional residual capacity, the gas-exchange and alveolar recruitment in brain injured patients. The measurements will be performed under sedation at different levels of PEEP. The following groups will be included: a) control patients withot lung injury and brain injury; b) brain injured patients without lung injury within the first 72 hours; c) brain injured patients without lung injury after 72 hours; d) brain injured patients with lung injury. Brain injury was defined as primary or secondary. Respiratory functional data will be related to intra-abdominal pressure.

Conditions

• Brain Injury
• Acute Lung Injury

Interventions

Type	Name	Description
OTHER	PEEP	Application of positive end expiratory pressure
OTHER	PEEP	Application of positive end-expiratory pressure
OTHER	PEEP	Application of positive end-expiratory pressure
OTHER	PEEP	Application of positive end-expiratory pressure

Timeline

• Start date: 2007-06-01
• Primary completion: 2008-12-01
• Completion: 2008-12-01
• First posted: 2008-03-20
• Last updated: 2008-03-20

Locations

1 site across 1 country: Italy