NCT00638560

Changes of Biomarkers in Response to Training and Antioxidant Treatment

Effects of Training and Antioxidant Treatment on Circulating Markers of Oxidative Stress and Skeletal Muscle mRNA Expression

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: University of Leipzig · Academic / Other
• Sex: Male
• Age: 25 Years – 35 Years
• Healthy volunteers: Accepted

Summary

The aim of the study is to compare the effects of an intensive 4 weeks exercise training program with or without additional treatment with antioxidants. 16 volunteers are included into the study and randomized into a treatment (n=8,Vitamine E 400 IU od + vitamine C 1g twice daily) and a non-treatment (n=8, training only) group. Before and after the training program, skeletal muscle biopsies will be taken to measure PGC-1alpha and PPARgamma mRNA expression. In addition before and after the training program individuals will have the following measurements: body weight, waist circumference, body fat content (DEXA scan), euglycemic-hyperinsulinemic clamps, ergospirometer (VO2 max), routine laboratory measurements, serum malondialdehyde concentrations.

Conditions

• Obesity
• Type 2 Diabetes

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Vitamin C, Vitamin E	Vitamin C, 1g po, twice daily Vitamin E, 400 IU po, once daily
DIETARY_SUPPLEMENT	Antioxidant treatment	no treatment

Timeline

• Start date: 2008-03-01
• Primary completion: 2008-10-01
• Completion: 2008-12-01
• First posted: 2008-03-19
• Last updated: 2010-01-20

Locations

1 site across 1 country: Germany